Effects of Electric Field Stress on a β-Amyloid Peptide

Subject:   Alzheimers....re electric field effects on amyloid (Dec. 2008)

To:    Mr. John Peterson   -    peterso4@niehs.nih.gov
Office of Communications

National Institute of Environmental Health Sciences


Dear Mr. Peterson:

In the past, you have referred me to the booklet, "EMF:  Electric and Magnetic Fields Associated with Use of Electric Power."

This is to advise that the booklet is seriously out-dated!   The following statement exemplifies just one of my concerns:

".........the results suggest that the presence of an EF, even for relatively short times, triggers the conversion of Aβ-(1−40) to the β-sheet structure, which is ultimately related to the β-amyloid aggregation typical of the Alzheimer’s disease plaques......."   [ File note:  quote from full text  -  

http://pubs.acs.org/doi/full/10.1021/jp807896g?cookieSet=1  -   jcm.....3-27-09 ]

I could provide a long list of recent studies and other information to support the vital need to update EMF facts, but will include link to the recent BioInitiative Study  -  http://www.bioinitiative.org/index.htm   -  at this time for sake of brevity and to help emphasize the importance of the study,  "Effects of Electric Field Stress on a β-Amyloid Peptide."  

Please direct my concerns to NIEHS personnel with responsibilities associated with enforcing the release of the EMF Interagency Committee Report to Congress (I have been informed that Dr. Imre Gyuk, Department of Energy has this report in his possession) as well as updating NIEHS EMF facts and properly releasing information to the public about the need to reduce close exposures to electric appliances, telephone equipment and any item with a speaker (magnet).   Close, chronic, prolonged nighttime exposures are particularly hazardous as are close, prolonged daytime exposures to cell phones, i-Pods, i-Phones, Blue Tooth, etc.

Re electronics and toys, see:   

Personal digital assistant (PDA) cell phone units produce elevated extremely-low frequency electromagnetic field emissions.       Sage C, Johansson O, Sage SA.

http://www.ncbi.nlm.nih.gov/pubmed/17357117?


Also my letter:  Sleep Sheep creating a tranquil environment?    http://freepage.twoday.net/stories/5137160/

Please coordinate my requests with proper officials in the Obama administration and/or advise me of the appropriate email addresses.    We will have no health system to dispute if warnings such as I suggest are not given the highest priority ranking!

Thank you for your prompt attention to these urgent matters!    Joanne

 

Joanne C. Mueller
Guinea Pigs "R" Us
731 - 123rd Avenue N.W.
Minneapolis, Minnesota  55448-2127 USA
Phone:   763-755-6114
Email:    jcmpelican@aol.com   (3-27-09)

 

WEBSITE:  http://guineapigsrus.org 

 

ARE YOU AND YOUR CHILDREN GUINEA PIGS?    Letter 7-22-04 by Joanne Mueller
http://omega.twoday.net/stories/282050/

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Effects of Electric Field Stress on a β-Amyloid Peptide



Francesca Toschi, Francesca Lugli, Fabio Biscarini and Francesco Zerbetto*

Dipartimento di Chimica “G. Ciamician”, Universit di Bologna, V. F. Selmi 2, 40126 Bologna, Italy, and ISMN CNR, V. Gobetti, Bologna, Italy

J. Phys. Chem. B, 2009, 113 (1), pp 369–376

DOI: 10.1021/jp807896g

Publication Date (Web): December 8, 2008

Copyright © 2008 American Chemical Society


Universit di Bologna.

,

ISMN CNR.

,

* Corresponding author. E-mail: francesco.zerbetto@unibo.it.

Abstract

The interaction of β-amyloid (Aβ) peptides with externally applied electric fields (EF) of varying strengths was investigated by means of molecular dynamics (MD) simulations. The results suggest that the EF favors the switch of Aβ-peptides from helical to β-sheet conformation, and a mechanism is tentatively proposed. Switching off the field does not restore the original conformation.

http://pubs.acs.org/doi/full/10.1021/jp807896g?cookieSet=1



[ http://omega.twoday.net/search?q=amyloid
http://omega.twoday.net/search?q=Alzheimer
http://freepage.twoday.net/search?q=Alzheimer
http://omega.twoday.net/search?q=electric+field
http://omega.twoday.net/search?q=BioInitiative ]